The Synthesis of 2-Imino-2,3-dihydro-1,3,4-selenadiazole Derivatives
نویسندگان
چکیده
منابع مشابه
New multi-1,2,3-selenadiazole aromatic derivatives.
The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydrochloride or ethyl hydrazine carboxylate into the...
متن کاملNew 1,2,3-selenadiazole and 1,2,3-thiadiazole derivatives.
New 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives, 14-23, were prepared from the ketones 1-5 via the corresponding semicarbazones or hydrazones 6-12. The Hurd-Mori and Lalezari methods were used, respectively, for the preparation of these 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives. The intermediate 13 was also trapped, separated and fully characterized. These derivatives are ...
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A one-pot synthesis ofdimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1Himidazol-1-yl)}-2-butenedioatesanddimethyl-2-[(alkoxycarbonyl)anilino]-2-butenedioates derivatives via reactions between dimethyl acetylenedicarboxylate,1-methylimidazoleand N-phenylcarbamates is described. The mild reaction condition, simple mixing of the starting materials and good yields exhibit the synthetic...
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INTRODUCTION Benzothiazine derivatives are of significant interest due to their chemotherapeutic history. The title compounds 4-aryl-8-arylidene-5,6-dihydro-2-imino-6,6dimethyl-4H,7H-[3,1]benzothiazines (Scheme 1) have been synthesized from 2,6-diarylidene-4-methyl cyclohexanone (IIA-H), characterized by IR, HNMR and mass spectroscopy. The final compounds were investigated for their anticonvuls...
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The Plasmodium falciparum cysteine protease falcipain-2, one of the most promising targets for antimalarial drug design, plays a key role in parasite survival as a major peptide hydrolase within the hemoglobin degradation pathway. In this work, a series of novel dihydroartemisinin derivatives based on (thio)semicarbazone scaffold were designed and synthesized as potential falcipain-2 inhibitors...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1980
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.53.1185